I wish just one pill would fix it! But, unfortunately for us, it does not. I was told to expect 6-8 weeks before a dose of Synthroid would be metabolized enough to show up on bloodwork. It is a very, very small dose. And, usually, by the time we are diagnosed and hypo, we are very sick people. So, easy does it, kiddo! This disease has a way of making us patient (even though we don’t like it). Whatever you do, don’t stop taking it without doc’s orders or you will get a whole lot sicker!! Joy in NoGA mtns.