Hi John – As I remember it Lisa had frequent blood work done following the first RAI treatment. She ended back on PTU and was stabalized for a second time. Fortunately, about a year later the second dose was successful. My heart goes out to all of you who are suffering with this disease. Hang in there with your doctors, but don’t be afraid to seek another opinion. That’s what we did. Lisa needed an endocrinologist that she felt comfortable with and trusted. IT DOES GET BETTER.