PTU did not effect me at all in fact I felt better after a few days!! When I was hyper I did not know I was hyper, I thought it was normal, I did not know I was totally out of wac!!! Give PTU time if it works for you great, I have been on PTU for well August will be a year! I have had a few sore throats but my white blood cell count came out fine and I’ve never had a fever…………… thank God! Kate