I had hives for nearly 5 days after I stopped the Tapazole. ( I also had facial and hand/feet swelling ). It was not until the ER visit on day 5 ,however, that I got ANY relief, despite a ton of oral Benadryl, oral Tagamet, and oral steroids. In the ER, I received IV steroids, IV Tagamet, IV Benadryl, and oral hydroxyzine. ( We were afraid to do the adrenalin because of tachycardia caused by the GD ). Within MINUTES, all my symptoms were gone…the Doc and staff all said I had ” the worst case of hives/rash ” they had ever seen. I continued high dose Prednisone by mouth for three days at home. AND I had RAI a week later. :>) ( The Doc said we could try PTU if I wanted to, but by then…I had had enough and agreed to be nuked.)