Ive changed my Tapazole dosage many times; skipped doctor appointments, etc. I monitor my weight, pulse and sleeping habits very closely. I’ve found I can do this just as well as any doctor. However, after a nearly two years on this drug I’ve found a state of equilibrium at around 7.5 miligrams per day. I can’t do without the Tapazole completely so I’ve decided to go for RAI treatment per my doctor’s advice.