From my experience definitely not unusual. 10mg is never quite enough and 15mg is too much, so currently I do 15mg Mon-Fri and 10mg Sat and Sun. Since starting Estrogen replacement I have found I need to watch the labs a little more closely and don’t appear to need quite as much methimazole. So may need to adjust this dosage again in a few weeks. Definitely becoming a bit more of a juggle as I get older. I understand now why the endo said “I would have an interesting menopause”.