I was diagnosed with Graves in June & put on Methimazole. After roughtly 3 1/2 weeks on it I developed ankle swelling & a rash on my ankles as well. I stopped the methimazole for 4 days (on advice of my endocrine Doc) & tried restarting it but got extremely nauseated & had almost flu-like symptoms. Needless to say, I stopped the med again & was told by my endocrine Doc that the next step will either be something called PTU or radioactive iodine. Has anyone else had these problems & what is the likelihood of this happening again with the PTU? I am really at a loss here-hope someone can help. Thanks!