I just recently had my blood retested after about a month taking methimazole. I had gained some weight and was hypo again. The doctor reduced my dose of methimazole and I will get blood retest again in a month. This is normal procedure to find the proper dosage of methimazole. Hopefully the reduced dosage will normalize my thyroid levels. I don’t want radiation ablation, as my sister had esophogeal cancer, and I’d rather avoid radiation. My daughter is hypo and on meds for that. She told me it took several trial and errors before they found the proper dosage for her, so I’ll just have to be patient until my blood tests let me know I’m receiving the proper dosage. Good luck to you, whatever treatment you choose.