@iGeek – I’m so sorry to hear that your family is going through this. Hopefully, your wife’s doctor is taking her symptoms seriously and doing everything possible to get her levels balanced out (and to rule out other possible conditions). If not, a second opinion might be helpful. A good place to start is the “Looking for a Doctor?” thread in the announcements section of the forum.
Using some form of T3/T4 combination therapy might also be worth a discussion with your wife’s doctor. It’s somewhat controversial in the medical community, and some patients actually find that it brings back a return of their hypER symptoms, such as hand tremors, rapid heart rate, insomnia, etc.. However, we hear from other patients swear that this is the only form of replacement hormone that gives them relief from hypO symptoms, and there are a few studies trickling out that seem to support this idea.
Wishing all the best for your and your family.