[Anonymous]

#1046366

Hi,
The rash on your feet can be a number of things and really
should be checked by a dermatologist or your doctor.
One aspect of Graves’ is a skin disorder called pretibial
myedexema.

Enclosed is a reprint of an article which outlines skin disorders with Graves’ disease.

Thyroid Disease and the Skin
J. Margesson, MD, FRCP(C)
Dermatologist, Kingston, Ontario
The skin is the covering on our bodies – “our bag”. It is made up of an outer layer called the epidermis. The epidermis itself is formed by stacks of skin cells like bricks with mortar between them. The bottom layer of the “brick wall” is made up of the mother cells. These cells divide on a regular basis and as these cells mature and progress up through the layers of bricks they eventually form a somewhat impermeable layer called the stratum corneum that protects us from our environment. Underneath the epidermis is the foundation layer or the dermis. The dermis is made up of connective tissue and in it are the blood vessels, nerves, glands and hair.
The functioning of the skin depends on the general status of the body and it is controlled by hormones like the thyroid. Hair growth particularly depends on thyroid hormone. Grease glands (sebaceous glands that produce grease or sebum) also are affected by the thyroid. The actual thickness of the skin depends on thyroid function.
Hyperthyroidism
Increased production of thyroid hormone is referred to as hyperthyroidism. The skin in this condition is warm, moist and smooth with increased pigmentation particularly on the palms and soles. Scalp hair is fine, soft and often diffusely thinned. With GRAVE’S DISEASE there are the usual changes of hyperthyroidism plus some special skin changes which are somewhat uncommon:
Pretibial myxedema – This is often associated with eye problems (protuberant eyes or exophthalmos). The skin of the shins gets thick with raised, indurated, plaques or nodules due to the deposition of altered material. Rarely other parts of the body can be involved – thighs, shoulders, forearms. At times the whole lower leg can be involved so that there is a solid swelling.
Thyroid acropathy – This is rare and there is clubbing of the fingers and toes with thickening of the soft tissue and sometimes the bones.
Note that pretibial myxedema can occur at any time in thyroid disease and sometimes there is no alteration in thyroid function at all or even low function.
Skin Changes in Hyperthyroidism
Thickening of the epidermis
Fast nail growth
Soft velvety dry skin
Increased pigmentation
Increased skin temperature
Diffuse thinned scalp hair
Red palms
Pruritus and hives (rare)
Flushed face
Pretibial myxedema
Increased sweating palms, soles
Acropathy (thick fingers and toes)
Hypothyroidism
In hypothyroidism there is a slow metabolic rate due to alteration of glandular function. This may be due to an autoimmune disease where for some reason the body destroys itself such as in HASHIMOTO’S THYROIDITIS or secondary failure due to tumour, infection or trauma. The slowed metabolic function results in insidious onset of tiredness, fatigue, leg cramps, etc. The skin is cold, dry and pale. The dryness can be extreme so that there is no sweating and the palms and soles get thick and dry (keratoderma).
The skin colour can be yellow due to alteration in Vitamin A metabolism – carotenemia.
Hair is lost all over – scalp, groin, even lateral eyebrows. Nails grow slowly and are brittle and thick.
The most common skin change is a generalized myxedema or swelling due to a build up of ground substance in the foundation of the skin (dermis). The skin is swollen, dry, pale and waxy. One can slowly develop a broad nose, swollen lips and puffy eyelids. Wounds heal slowly.
Skin Changes in Hypothyroidism
Pale, cold, scaly, wrinkled skin
Coarse, dry scalp and hair
Absence of sweating
Hair loss – scalp groin, lateral eyebrows, etc.
Skin colour – ivory – yellow
Puffy edema (hands, face, eyelids)
Brittle thick nails
Eczema craquele
Bruising
Poor wound healing
Thyroid disorders are sometimes associated with other diseases and skin changes.
Alopecia Areata is a condition in which there is sudden loss of circular areas of scalp hair and at times there can be generalized loss of scalp and body hair. Thus it may be patchy or generalized.
Pemphigus/Pemphigoid are autoimmune blistering disorders of the skin in which one can develop open sores on the skin in cases of Pemphigus or large blisters of the skin and itching as in bullous pemphigoid.
Lupus erythematosus is a condition of unknown etiology in which inflammation in the body develops a variety of patterns. Many organs can be involved: brain, heart, lung, skin, kidney, joints, etc. The skin changes are variable but can result in well defined scaling, scarring lesions or fixed red, circular rashes most notably over sun exposed areas.
Vitiligo is white patch disease. Here the body has rejected the pigment cells of the skin resulting in the onset of areas of varying size with no pigment, particularly over the joints – knuckles of the fingers, wrists, knees, etc. The resulting colour change makes one look almost like a “pinto pony”. These areas sunburn very easily.
Scleroderma is a condition in which the skin becomes very scarred and bound down, at times resulting in contractures of the fingers with ulceration of fingertips and loss of function.
Overall the most common problem associated with thyroid disease is dry skin associated with hypothyroidism. This is worse in the winter with low humidity and is aggravated as we get older.
Treatment for dry skin:
Avoid harsh irritating soaps and lotions.
Use a cleansing bar just where one is dirty – hands, groin, axilla.
Have a soak in the tub daily (not too hot).
After soak use a moisturizer applied to the skin while the skin is moist to hold the moisture in. A simple formula is to mix Vaseline/Petrolatum 50-50 with an inexpensive cream. (Creams or lotions are usually too light to hold moisture in effectively on their own and Vaseline by itself is often too greasy).

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