One of the drawbacks of PTU is that it tastes terrible. I do not remember that bad taste lingering, but most of that time in my life is a bit of a blur. I remember trying to swallow those pills very quickly, so that they did not linger in my mouth for any length of time.
If I remember correctly, PTU has a relatively short life-span, biologically, which is why we are typically instructed to take it three times a day. I found that i needed to take the doses roughly eight hours apart to keep hyper symptoms from emerging. That is difficult, given that one of the doses has to be late at night, and I was usually extremely tired by then. So, space things out as evenly as you can to get the optimal benefit from the drug.
For me, the PTU affected cognitive activities. I felt as though my brain waves were having to wade through molasses: I could not remember much of anything; thinking processes were slow. People here on the board told me that all that was just the disease, but I decided it was the drug, a personal reaction to the drug, and told my endo to go ahead with RAI. I never again experienced that sloggy, slow brain function, so I think that I was right. Nevertheless, it is important to check blood work to make sure that you aren’t on too much of the drug: being hypo can slow down the brain, too.
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