[smj August 6, 2012 at 6:19 pm Post count: 6]

#1059257

Hi- I think I lost my last post.

I have Graves and am HypoT after RAI. My daughter was born on 5/26 with neonatal hyperT. She was placed on methimazole. After about 5 weeks, her levels stabilized. While the endo usually slowly decreases the meds to assure that the antibodies are out ofher system, this time they discontinued the meds b/c her liver enzyme was elevated slightly. At that time, only the SGPT was elevated to 80 (normal being 5-50).

She has been off the meds for 5 weeks and they anticipated the liver returning to normal. She had blood work today. They did not have the thryoid levels back but her LFT came back. This time, the SGPT went to 100 and now her SGOT went from 45(normal) to 76 (normal range is under 65).

They just want to repeat it in 4 weeks, but now I am so nervous. Any ideas of why this would happen since she has been off the meds?

[KimberlyOnline Facilitator August 7, 2012 at 10:35 am Post count: 4294]

#1173426

Hello and welcome to the forum.

All new members have to have their very first post manually approved by a moderator before it shows up on the forum. Unfortunately, we have to do this to keep spammers from completely clogging up the boards.

I’m so sorry that you and your daughter are going through this. We are fellow patients here, not doctors, so your own doc is in the best position to speculate on what is going on.

However, I do know that hyperthyroidism in itself can cause liver function tests to go out of range, and I don’t know how quickly you can expect them to go back to normal after hyperthyroidism resolves. And the test results generally need to be significantly outside the “normal” range (2-3 times the upper limit) before there is concern that it’s the meds that are causing the issue.

Hopefully, you will see things settle down over the next few weeks, but make sure that your doctor keeps you up to date on symptoms to watch out for that might indicate potential liver problems — and what action to take if you do spot these issues. These can include itching, rash, yellowing of the skin or eyes, light-colored stool or dark urine, joint pain, right upper abdominal pain or abdominal bloating.

Take care — and please keep us posted.

[snelsen August 7, 2012 at 11:00 am Post count: 1909]

#1173427

I am guessing you already have a pediatric endocrinologist involved in her care. I’d ask for more information and the bigger picture, so you feel more comfortable with the plan when you understand it. If you continue to have a lot of concern, try for a 2nd opinion. Although i know ped endos are not abundant.
Kimberly had good advice. Report any of the symptoms she mentioned, and also check with the ped endo, asking the same question of him if you have not already been told, or if you want reassurance with this.
Congratulations on your new baby girl/ Sounds like she is having good care.
Shirley

[smj August 14, 2012 at 11:50 am Post count: 6]

#1173428

Thank you for the advice.

I have asked a million people, including the pediatric endocronologist. It just seems like this is so rare to happen, that she does not even have really strong advice here.

When your specialist tells you she is “perplexed” that this happn, your anxiety goes up really quick.

I will be seeing a pediatric GI, who specializes in the liver, this Friday.

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