[snelsen]

#1176391

Hi,
I bet my bottom nickel that it is not an evidenced based, long term (which would essential for the study) with a large population and a control group…
This information regarding TSI and the right brain sounds downright silly.
I do not think his website is professional, nor do I respect his references.
But it has a catchy name. Just my two cents. Academic endocrine departments, and NIH might be better references to explore any research.
Shirley

[Kimberly]

#1176392

Hello – I’m a little confused on the web site reference, as thyroid.org is the American Thyroid Association, which is a highly credible site. I am not familiar with the study that you mentioned, nor have I seen it posted on their web site. Before posting any other links, please keep in mind that we have guidelines for posting links on this forum, which you can check out in the “New User? Read This First!” thread at the top of the forum. Any links that do not meet the guidelines will be removed, as we want to make sure that our members here are getting credible information.

I have not seen any studies regarding treatment options and levels of TSI (which is specific to the Graves’ antibodies that cause stimulation). However, there was a study done on TRAb, which indicated on average that surgery and anti-thyroid drugs brought a similar decline in antibody levels, while RAI brought a temporary spike in antibody levels:

http://www.eje-online.org/content/158/1/69.long

Keep in mind that the numbers in the chart represent the *average* of all the patients in the study, so any one individual might have had significantly different results from the rest of the group. In other words, your mileage may vary.

Hope this helps!

[snelsen]

#1176393

Interesting. The website I found was all advertisements of one guy. I will have to look it up again. Don’t recall his name. the web can be like that.
Will let you know.
s

[Kimberly]

#1176394

snelsen wrote:

Interesting. The website I found was all advertisements of one guy. I will have to look it up again. Don’t recall his name. the web can be like that.
Will let you know.
s

Very strange! If you see that again when you click on the thyroid.org link, could you try and get a screen shot? (Not sure about a mobile, but on a regular computer, you can select the “Print Screen” key and then paste it into a Word document or e-mail using CTRL+v.)

Thanks!

[snelsen]

#1176395

My mistake. I inadvertently typed:
Thyroid.com (not org.)
Just a frail human being, I guess! (:
Shirley

[catstuart7]

#1176396

Bella1 wrote:

Kimberly wrote:

In an attempt to find some answers about TSI effects and remission, I came across an article yesterday at Thyroid.org in the New Research section which has a new study (backed up by 2 previous studies) that shows that Graves’ TSI also affects thyroid-like tissue in the brain. I wasn’t able to find the link to the study when I went back, but they were able to show damage and diminished blood flow to the right frontal lobe (rational thought and decision-making), which may be the cause of the emotional and cognitive side effects of TSI. The worst part was that they believed the damage done to the brain tissue may not be reversible even when or if TSI is reduced. So we may have more to worry about than just eye and heart damage from sustained high levels of TSI.

Kimberly, would you know if TSI reduction is more likely with drug, RAI or TT treatment? Because that seems to be the imperative in Graves treatment.

Thanks.

Hi Bella, I’d be very interested in that study if you find it again. What Kimberly said is the official word I’ve read too – it’s either the normalizing of the thyroid levels and/or the ATD meds themselves that reduce the antibodies but they don’t know yet. If you use the search function you might find the thread where someone posted a study on that – think it was within the last three months.

[flower]

#1176397

Hi Kimberly,

I wanted to thank you again for calling me last evening and giving me this website. I think that it will be very helpful to me.

[Bella1]

#1176398

catstuart7 and Kimberly wrote:

Thank you both so much as this is exactly the question I’m trying to answer. I know its because its all new to me, but I’m trying to become as educated as possible to find the best solutions. I appreciate the time you are both taking to explain things to me.

And Kimberly, I am sorry I posted info inappropriately about the study I found. I will be more vigilant in future.

[Kimberly]

#1176399

@flower – Welcome! Now that this first post has gone through, your remaining posts will show up immediately. Please feel free to jump in!

@Bella1 – No worries! We just want to make sure that any studies posted here come from a credible medical association, university hospital, peer-reviewed journal, etc..

[flower]

#1176400

Hi Bella my name is Susan and I am new to the website. I don’t know what took me so long to find this support group??? I always think I can handle everything all by myself but graves disease is very complicated as you know. I was diagnosed (2) yrs ago and it has been a roller coaster ever since. I can relate to your personality. I was also very outgoing but I now find myself disconected from family and friends even co-workers. My mind feels cluttered. Sometimes I don’t know if its just me. I don’t feel like the same person that I was before I was diagnosed. Its hard to explain.

[Bella1]

#1176401

Hi Susan,

I know what you mean. Suddenly I’m not “me”. It’s almost like a form of agoraphobia. Now I’m an extrovert who doesn’t want to be around people. I also try to deal with everything myself. Not possible when you don’t have the info you need, which is why I was also motivated to find this website. I’m no expert, as I was just diagnosed the end of September, but I’ve already found an immense amount of info and support here. For me, just finding someone who had Graves and was overweight besides me was very validating. Yesterday I saw that as many as 15% of Graves patients have weight gain due to Graves. Who knew?!

Last week I too felt kinda crazy and like I’d become someone I couldn’t relate to or control. But people here said wait til your meds stabilize, and they were right. In one week I’m so much better. So all I can say is hang in there. I don’t yet know much more than that.

[Author]

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