[Harpy]

#1059941

Home alone, bored, it’s late and presto,
Here’s a little Gem,
As there has been a bit of discussion regarding Anti-Inflamatory diets, this seems to go with the flow, for those unaware Oxidation and Inflamation are used interchangably.
Although not the same as all the suppliments we used, the ideas were the same, to reduce inflamation, good to see some documented positive results.

Well worth a read, lots of other good info in it, I didn’t realise that both PTU & MMi have some anti-oxidant properties and this is likely also a part of their action.

http://www.karger.com/Article/FullText/337976

Quote:

Conclusions
There is a body of evidence indicating Graves’ hyperthyroidism is characterized by increased oxidative stress and that increased free radicals might be responsible for some symptoms and signs of hyperthyroidism. Indeed, antioxidant treatment, without changing the serum concentrations of thyroid hormones, may improve some clinical manifestations of hyperthyroidism. Restoration of euthyroidism with ATD improves and often normalizes the oxidative status. Oxidative stress is also involved in the pathogenesis of GO and evidence for an imbalance in the oxidative status has been provided in patients with GO. A beneficial effect of antioxidant therapy has been shown in mild GO. Future studies should evaluate whether antioxidant therapy may have a role in association with ATD for the control of symptoms and signs related to increased thyroid hormone levels as well as influence the rate of relapse after ATD therapy. Further studies should evaluate whether selenium supplementation may also be beneficial in patients with moderately severe GO (in association with immunosuppressive therapy).

Quote:

Two studies have extended these observations.

Guerra et al. [31] treated 56 patients with hyperthyroid GD with different treatment schedules: (1) methimazole alone, (2) an antioxidant mixture (Larotabe®, containing vitamin E, β-carotene, vitamin C, Cu, Zn, Mn, and selenium) alone, or (3) a combination of methimazole and Larotabe (fig. 2). Serum concentration of total thyroid hormones, TSH, MDA, and erythrocyte SOD and CAT were measured before and after completion of therapy. A clinical score based on common symptoms and signs of hyperthyroidism was also recorded. Treatment with methimazole normalized thyroid function and MDA levels and improved the clinical score. Antioxidant treatment alone did not affect serum concentration of thyroid hormones, which remained elevated but significantly decreased the clinical score and normalized MDA levels. Combined treatment shortened the time required to normalize thyroid hormones and the clinical score. These data suggest that increased ROS generation may contribute to generate some clinical manifestations of thyrotoxicosis and that antioxidant treatment may improve the clinical picture, even if serum thyroid hormones remain elevated. The faster control of hyperthyroidism in patients treated with methimazole and Larotabe suggest a synergistic mechanism at the level of thyroid hormone synthesis.

Vrca et al. [32] confirmed a beneficial effect of antioxidant supplementation to methimazole. These authors evaluated 57 patients with GD randomly treated for 2 months with methimazole alone or combined with a mixture of antioxidant containing β-carotene, vitamin C, vitamin E, and selenium (Symbion®). Patients who were treated with methimazole plus antiodixant supplementation reached euthyroidism earlier than those given methimazole alone. Whole blood GPx activity increased in both groups, but a significantly greater increase was observed at 1 month in patients who received the combined therapy compared with those treated with methimazole alone.

Based on the latter findings it might be reasonable to consider antioxidant supplementation in the early phase of ADT therapy in order to obtain a more rapid control of clinical manifestations and a faster achievement of euthyroidism. Further studies on larger series of hyperthyroid patients are needed to confirm these preliminary results.

[Harpy]

#1178932

This one is similar, but focuses more on Selenium in studies
http://www.hindawi.com/journals/jtr/2012/736161/

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