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    I often take things like Tylenol or even Pepcid or an antihistamine with my levothyroxine in the morning. You can wait and take after an hour, but if I wake up with a headache or allergies, I just go ahead and take together on an empty stomach, no problem. Obviously, you would not take calcium or magnesium, etc with the levothyroxine. You can also take meds at night four hours after eating which qualifies as empty stomach. It is all about being consistent. I know people who always have coffee first thing in the morning with their levothyroxine. They end up being on a slightly higher dose to compensate for the coffee’s interference with absorption.