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    Hello and welcome – Keep in mind that the initial dosage of replacement hormone post surgery is the doctor’s best guess, based on weight, age, and whether there are any other coexisting medical conditions. (For example, someone with a heart condition would be started on a lower dose). Dosage ajustments post-surgery are common.

    One issue to consider is to ensure that you are following the time restrictions regarding food and supplements to ensure maximum absorption of replacement hormone. The general rule is to take the pills first thing in the a.m. and then wait 30-60 minutes to have breakfast. Also, calcium/iron supplements and soy should be taken 4 hours apart from Synthroid, to avoid interference with absorption.

    A study came out a while ago suggesting that some patients might do better by taking their replacement hormone at night, rather than in the morning. The idea is that because metabolism slows down at night, more of the drug is actually absorbed into the system. If you are still having issues after your next set of labs, this might be worth discussing with your doctor.

    Another option to discuss with your doctor is that there is a fairly new drug on the market called Tirosint that is the same active ingredient as Synthroid, but it comes in liquid form. The *theory* is that absorption should be more consistent with a liquid tab.

    Hope that you can get things leveled out and hit that “sweet spot” soon!