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    I’ve heard that PTU can cause muscle cramps/ spasms (like methimazole can cause hives). I had liver issues with methimazole, so I had to stop it as well. PTU wasn’t recommended to me bc of it being likely to have issues with PTU (liver wise) if one had them with methimazole. You can see on my siggy below that I opted for surgery. I have to tell you that I’m now 2 plus months post surgery and am starting to feel pretty darn good again! My Synthroid was upped to 112 mcg in the last 3 weeks, and I’m feeling better. Not perfect yet, but much, much better. If PTU ends up being the cause of your muscle cramps, I would suggest entertaining RAI or surgery. It feels good to be myself again (or close to it) and know that I don’t have to worry about being hyper anymore. Good luck!