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    @Alexis – My understanding is that T4 has a “half-life” of approximately seven days. This means that when you take a dose of meds (or your body produces some T4) today, half of that amount will still be in your system in 7 days…one-fourth will remain in 14 days…then one-eighth will be left in 28 days. So it should take a few weeks to fully see the results of any type of change (starting meds, changing dose, etc.). Take care!