[mickiko]

#1059267

From what you guys have read, which do you think is the better study and why? Or, in another way, if you could only have one test to take as baseline and continue to monitor throughout your disease, either TRAb or TSI, which would you have and why?

The reason why I’m asking is because I’ve read the ATA (American Thyroid Assoc.) guidelines and I thought they said you should have a TRAb to help make a diagnosis and that the TSI was not as sensitive. But then my endocrinologist said the TSI is the gold standard. She did admit, however, that she used to get TRAb on all her patients, but then her lab dropped TRAb so she started using TSI now. She said the main thing that matters is sticking with one and using that to monitor your disease status.

TIA (Thanks in advance.)
mk

[mickiko]

#1173741

Also, I’ve noticed that my TSI levels and the lab’s normal range for TSI is different than others on this forum.

My TSI level is 198 with normal being < 140%

[Kimberly]

#1173742

Hello – It’s quite common for labs to use slightly different “normal” ranges…that’s one reason why it’s helpful to get a hard copy of your lab reports so you can see for yourself what range is being used.

TRAb measures total antibody activity, while TSI is more specific to the antibodies that cause stimulation of the thyroid gland. I have not heard that one is “better” than the other for purposes of diagnosis and treatment, but this would be a good question for the docs at our upcoming conference!

[Carito71]

#1173743

Hello Mickiko.

Good questions. Wish I knew. My Drs have only asked for TSI and TPOab testing.

The TSI was done twice. Each time the normal range was different, so I don’t know if things got better or worst in b/w labs.

TSI
ER:
Results: 4.5 (normal range < EQ 1.3) 1 week later @ Dr.’s:
Results: 237 (normal range 0-139%)

I haven’t had an iodine scan but I was told I have GD based on the TSI #.

I’m also very interested in the immunogology part of GD. Please let us know if you find out anything about your question. I’m curious to read your findings.

Caro

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